GLP-1s, Microdosing & Metabolism: What Most People Are Getting Wrong

Natalie
3 hours ago
36 min read

If you’re considering GLP-1 medications—or already using them—this is the conversation you need before you go any further.

GLP-1 medications have quickly become one of the most talked-about tools in weight loss.

But behind the headlines and quick results, there’s a bigger story—one that most people aren’t being told.

In this episode, I sit down with peptide expert and author Jay Campbell to talk about what’s really happening with GLP-1s, why so many people are using them incorrectly, and how dosage, lifestyle, and hormone health all play a critical role in the outcome.

Because this isn’t just about losing weight.

It’s about protecting your metabolism, your muscle, and your long-term health.

What You’ll Learn

Why most people are starting GLP-1s at the wrong dose
The difference between GLP-1, GLP-2, and GLP-3
What “microdosing” is—and why it may be a smarter approach
The real risks of losing weight too quickly
How muscle loss, hormones, and protein intake impact results
Why lifestyle habits still matter—no matter what you’re taking
What to know before working with a doctor or online provider

Why This Matters

There’s a growing number of women in midlife turning to GLP-1 medications—and many are seeing results.

But others are losing too much weight, losing muscle, or struggling to maintain progress once they stop.

This episode is about stepping back and asking better questions.

Not just “Does it work?”

But “Is it working for my body long-term?”

About Jay Campbell

Jay Campbell is an author and expert in peptides, hormones, and longevity. His latest book, Metabolic Awakening with GLP Peptides, focuses on how these medications can be used more effectively—and more responsibly—within a broader health strategy.

Links & Resources

Naked Gut Health - Clean, science-backed probiotic formulations designed to support gut balance, digestion, and immune resilience.

Jay Campbell’s new book: Metabolic Awakening with GLP Peptides

Connect with Jay

Related episode: The Loud Wellness Industry

If this episode helped you better understand your options, share it with someone who’s been considering GLP-1s.

And be sure to follow The Natalie Tysdal Podcast for more conversations on health, hormones, and aging well.

Instagram: https://www.instagram.com/ntysdal

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DISCLAIMER

Natalie Tysdal is a health journalist, not a licensed medical professional. The information shared in this episode is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment.

Transcript

Natalie Tysdal (03:08)

Jay, great to have you on today. I know you're celebrating as your newest book has just been released.

Jay Campbell (03:14)

It has Natalie, it's an honor to be here with you. I'm really looking forward to this conversation.

Natalie Tysdal (03:18)

I have done a lot of interviews on hormones and specifically on GLP-1s. You have a little bit different take on it because it is your hyper focus. What is your favorite part about what you do and what's the most difficult part of what you do in helping people balance these things?

My favorite part is just getting the opportunity every day to speak to people like

Jay Campbell (03:39)

My favorite part is just getting the opportunity every day to speak to people like you who

are very passionate about helping others. I'm a service to others being.

Natalie Tysdal (03:46)

service to

Jay Campbell (03:48)

And I love to talk to people about helping them with their health. I think really, honestly, once you dial in your health, then you can really talk about raising your consciousness, which is huge. You know, this planet is at a crossroads right now with people picking to either be, as I call it, empowered, sovereign and free with their health or, you know, outsourcing their health to the system, which, as you know, is collapsing all around. So we all get a choice to that. And then I think the thing that is most difficult for me is the system is collapsing.

Natalie Tysdal (03:51)

think really honestly once you dial in your health and you...

This planet is a crossroads right now with people picking to either be as I call it empowered, sovereign and free with their health or outsourcing their health to the system which as you know is collapsing all around. So we all get a choice to that. And then I think the thing that's most difficult for me is the system is collapsing,

Jay Campbell (04:18)

and people's health is collapsing. And the average person in America today is fat, inflamed,

Natalie Tysdal (04:18)

people's health is collapsing. The average person in America today is fat and flamed.

Jay Campbell (04:24)

and disenchanted and disenfranchised. So it's a tough call, I think, in society today on who we can work with and who we can't. But as I always say, we get a choice every day to how we decide we want to live. And if you want to live empowered, again, sovereign and free, it's up to you to take personalized care of your health.

Natalie Tysdal (04:25)

disenchanted and disenfranchised.

tough call, think, in society to say who we can work with and who we can't. But as I always say, we get a choice every day to how we want to live. We want to live empowered, again, sovereign and free. It's up to you to take personalized care of it.

Well, it's one of the things I talk about the most as a health journalist is that you have to understand. You actually have to do your research. You have to be informed. You can't just walk into an office and walk out and assume that what you're getting or what you've been prescribed is what's best for you, which is really sad.

Jay Campbell (04:49)

Yes.

Natalie Tysdal (04:57)

I mean, you think about it growing up, I think we're the same age that we trusted our medical care providers. And it's not that we shouldn't trust. They have good care. They're just not being taught many of the things ⁓ that are new today and that can help them and they might not know about.

Jay Campbell (05:16)

Natalie, are you telling me you're 55? Because you

a lot better than that. You actually look amazing for 55. That's great. Good for you. So

Natalie Tysdal (05:19)

I know exactly how old you are because I did my research and you're you are ⁓ three months older than me.

Jay Campbell (05:27)

I'm Pisces. What are you? What's after Pisces?

Natalie Tysdal (05:29)

I'm a Taurus.

Jay Campbell (05:31)

Tourists,

got

got it, got it. Well, you look amazing. So obviously you're taking care of yourself. I agree with you. I always say this when I'm speaking or lecturing or talking to my private communities. I say, if you went into your family doctor or your insurance, know, subrogated doctor and said, hey doc, help me to live to 150. It'd look at you like you were insane. They'd be like, what you talking about? Open up your mouth, say, ah, you know, whatever. Let let me, let me register your heart.

So it's like, like you said, it is insane, but we really are in this like inverted system where the current healthcare is sick care, it's illness medicine. And it's on us to what I say to become the personal.

Natalie Tysdal (05:57)

said it is insane, we really are in this inverted system where the current healthcare is sick care. On us, to what I say, to become the really

want to call it the empowered scientist for your own health. No one is out there looking over your health records or attempting to look through.

Jay Campbell (06:12)

or if you really want to call it like the empowered personal scientist for your own health, because no one is out there looking over your health records or attempting to look through algorithms

and stuff to see what you're going to need over the next 40 to 50 years of your life. So if you really truly want to live optimally or age optimally, it's totally on you.

Natalie Tysdal (06:25)

you're going to need over the next 40 to 50 years of your life. So if you really truly want to live familiar age optimally, totally on

Well, let's get a little bit more into then hormones. And I want to talk about GLP-1s. Obviously, that's really popular today. But we're starting to see people who have been doing this for a year or two who are really thin. We hear a lot of things like really thin, almost addicted to the GLP-1, but not doing all the other things that

make it a healthy ⁓ suggestion or alternative for them. So how did you get into this and how do you help people balance those

Jay Campbell (07:06)

Sure, so I got into working with GLPs because my doctor who actually writes the foreword to this book, name is Dr. Rudolph Everwine, who's one of the world's foremost GLP prescribing doctors. He's actually been prescribing them since 2008.

Natalie Tysdal (07:09)

working with GLPs because.

eat

Jay Campbell (07:20)

So they've been around a lot longer than

Natalie Tysdal (07:20)

so they've been a long they've been around a while

Jay Campbell (07:22)

most people understand, and they were very crude and very rude at that point, but now they've obviously evolved into what they are now today. But the truth is, and this is in my book, and the book is called Metabolic Awakening with GLP Peptides, and it does launch tomorrow globally. ⁓ 95 % of people who use GLPs or who have used GLPs have done it wrong. And what I mean by that is that, and you and I were talking about this off air, the doctor who prescribes them has no education.

Natalie Tysdal (07:25)

They were very crude and very rude at that point.

book is called metabolic awakening with glp peptides and it does launch tomorrow globally 95 % of people who use glps or who have used glps have done it wrong i mean by that is that you and i were talking about this off air the doctor who prescribes them no education

Jay Campbell (07:50)

other than maybe a weekend course or seminar and the pharmaceutical rep that tells them how to sell that only tells them to start at very high pharmacological doses

Natalie Tysdal (07:51)

and maybe a weekend course seminar pharmaceutical rep that tells them how to sell that only tells them to start at very high pharmacological doses

Jay Campbell (08:00)

and then to titrate the doses higher and higher and higher. So all of these people that start out, know, to use these to suppress appetite, to lose body fat or lose weight, do them wrong because they're taking a dose that's pharmacologically too high for their body.

And so over time, two weeks, four weeks, six weeks, eight weeks, they saturate their receptors and they also stop eating the majority of these people because they're such powerful drugs. And obviously, as you know, you talked about the side effects and the things that happen to them. They become too thin, they lose muscle. They actually dysregulate thyroid. There's a lot of negative things that happen. These are all caused because the dose is too high and most importantly, the people are not living the correct lifestyle.

Natalie Tysdal (08:31)

They actually just regulate thyroid there's a lot of negative things that happen. They're all caused because the dose is too high. Most importantly, the people are not living the correct lifestyle.

Lifestyle has to be education of the physician, clinical director, whoever it is that's prescribing because honestly, it's not just doctors, it's PAs.

Jay Campbell (08:44)

And the lifestyle has to be from the education of the physician or the clinical director, whoever it is that's prescribing. Cause obviously it's not just doctors, it's NPs, PAs. You can

get them from the research community, et cetera. So as you said, you have to do your own homework and research and truly understand how to use these things in the context of health and longevity. And my book really does an amazing job of showing people how to do this right.

Natalie Tysdal (08:54)

You can get them from the research community, et cetera. As you said, you have to do your own research, truly understand how to use these things in context of health and longevity. And my book really does an amazing job of showing people how to do this

right. But it also goes through all the potential negative side effects. So if you're one of those people that has never used them, actually a good thing, and fear of using them, you can actually read this book and learn how to do these things correctly, because very truthfully.

Jay Campbell (09:11)

but it also goes through all the potential negative side effects. So if you're one of those people that has never used them, which is actually a good thing, and you're in fear of using them, you could actually read this book to learn how to do these things correctly, because very truthfully, and

this is the one thing that most of the public doesn't understand, the clinical research in these products is amazing. They rewire the brain, they break obsessive-compulsive disorders, they cure gambling addictions, porn addiction.

Natalie Tysdal (09:24)

the one thing that most of the public doesn't understand, the clinical research of these products is amazing. They rewire pain.

Jay Campbell (09:39)

alcohol addictions, food addictions, they do a lot of really good things. But again, the difference between a pill and a poison is always the dosage. And so we have to dose these appropriately and pharma is not teaching people how to dose these appropriately because pharma wants to make money as you know, as your audience knows. And so it's up to people like me, other researchers, subject matter experts, know, clinicians to teach people how to use these in the context of improving health and longevity.

Natalie Tysdal (09:52)

And so it's to people like me.

other researchers, subject matter experts, know, clinicians to teach people how to use these in the context of improving health and

So what specifically, give me some examples. mean, I know people who started at low doses and I know some people just start right at the high dose. They go up and then they can't go down without gaining some weight back. What are the things we're missing? I know weightlifting is a big deal, but what are the things we're missing that can make them optimal?

Yeah. So number one is hormonal

Jay Campbell (10:26)

Yeah, so number one is hormonal

dysregulation or hormonal optimization or balance. And most people who use these things are not checking for that, right? The doctors that prescribe these things are not looking into their hormones, they're not looking to see if they're balanced or they're hormonally optimized. And so if you start these drugs and you're not hormonally balanced, you're hormonally dysregulated, and again, the majority of adults in America especially are at this point today, ⁓ you will lose muscle most likely because they're so powerful.

Natalie Tysdal (10:29)

dysregulation.

checking for that, right? The doctors that prescribe these things are.

And so if you start these drugs, you're not hormonally balanced, you're hormonally dysregulated.

⁓ You will lose muscle most likely because they're so powerful.

Jay Campbell (10:56)

The other things to really keep in mind, you already talked about is weightlifting, resistance training, bone-bearing training. You have to do that if you're using even a microdose of these because again, they're so powerful from an appetite suppression and metabolic stimulation. So the other thing is protein. You see this in women. Women will stop eating food completely when they go on

Natalie Tysdal (10:56)

The other things to really keep in mind you already talked about is weight lifting, resistance training, bone bearing training. You have to do that if you're using even a micro dose of these because again, they're so powerful from an appetite suppression and metabolic stimulation. So the other thing is protein. You see this in women. Women will stop eating food completely when they...

Jay Campbell (11:18)

these, even at microdosages because again, it

Natalie Tysdal (11:19)

micro dosages because again,

Jay Campbell (11:21)

their appetite and yeah, exactly.

Natalie Tysdal (11:21)

They're just not hungry. They're like, this is great. I'm not taking in the calories.

Jay Campbell (11:25)

But that's

huge thing, right? Because we have to understand that you can't just stop eating and think that you're going

Natalie Tysdal (11:26)

a huge thing, right? Because we have to understand that you can't just stop eating and think.

Jay Campbell (11:30)

to lose weight. And the problem is, is that they do lose the weight initially, right? But then they have three weeks later, as I call it, haywire to deal with because their thyroid collapses. They do start losing muscle. Their hair falls out. They get a wigoby face, wigoby neck, wigoby butt. All these things happen due to catabolism and muscle loss. But they're all totally avoidable.

Natalie Tysdal (11:32)

is that they do lose the weight initially. But then they have three weeks later, as I call it, haywire to deal with because their thyroid, they do start losing muscle. Their hair falls out. They get a goby face, goby neck, goby butt. All these things happen due to catabolism and muscle loss. But they're all totally avoidable

Jay Campbell (11:52)

if you do these lifestyle things. And again, you if I'm just going to say four things right away, it's number one, are you hormonally optimized? Number two, are you eating enough protein? Almost everyone, especially

Natalie Tysdal (11:52)

if you do these lifestyle things. And again, if I'm just going to say four things right away, it's number one, you hormonally optimized? Number two, are you eating enough?

Jay Campbell (12:01)

women or protein malnourished. Number three, are you doing resistance training? And then number four, you know, it's lifestyle, right? Are you getting enough sleep? You know, are you doing cardiovascular training? Are you mitigating EMF, et cetera? But if you do those four or five things and you use a micro dose, we can get into what the effective dosages are.

Natalie Tysdal (12:01)

women or protein malnourished. Number three, are you doing resistance training? Number four, know, it's lifestyle, right? Are you getting enough sleep? You know, are you doing cardiovascular training? Are you mitigating EMF, et cetera? If you do those four or five things,

If you use a micro dose, we can get into what the of dosages

are. I rarely see people with side effects and you can absolutely come off of them and stay off of them without weight regain.

Jay Campbell (12:20)

⁓ I rarely see people with side effects and you can absolutely come off of them and stay off of them without weight regain.

Natalie Tysdal (12:28)

But then as you're talking about the micro dosing, there are benefits beyond the weight that you might be of like the perfect weight. Not many people are perfectly happy with their weight, but you could be getting the inflammatory.

Jay Campbell (12:33)

Exactly.

Natalie Tysdal (12:43)

⁓ benefits, the brain benefits, all of those things. Talk about what those things are and are there people who are just going after the GLPs just for that?

Jay Campbell (12:52)

Yes, 100 % they are. And that's where the studies really show incredible benefit. Like for example, my wife is 54 years old and she's 5'4 and about 129, 130 pounds and she's very muscular woman. She has an amazing physique. And she uses a tiny, tiny micro dose of Rhebutrutide to eliminate food noise. That's it, right? Like she doesn't overeat. She's not trying to lose body fat. She just uses it because it makes her more effective.

Natalie Tysdal (13:06)

and she uses a tiny, tiny microdose of Brutrutide to eliminate food poisoning.

trying to lose body fat. just uses it because it makes her more effective

during the late afternoon stages of the day, whether that you're thinking about even a chocolate chip cookie or something emotional based, which it does this for everyone. And again, that's the thing about, you know, GLP two and GLP three is that in studies, it shows that it rewires synaptic ⁓ serotonergic and dopaminergic signaling pathways in the brain.

Jay Campbell (13:19)

you know, during the late afternoon stages of the day, whether the, you know, thinking about eating a chocolate chip cookie or something emotional based, which it does this for everyone. And again, that's the thing about, you know, GLP two and GLP three is that in the studies, shows that it rewires, synaptic, ⁓ serotonergic and dopaminergic signaling pathways in the brain. And

so it basically cures you of food noise, obsessive compulsive disorders, you know, just negative thought processes that a lot of people have.

Natalie Tysdal (13:39)

And so it basically cures you with food noise, obsessive compulsive disorders, negative thought processes that a lot of people have

that they can now be cured by using a microdose of this. And truthfully, Natalie, the craziest part, and this is in the studies, you're cured from using a microdose and rewiring them per se, 12 weeks, 10 weeks, they come back.

Jay Campbell (13:49)

that they can now be cured by using a microdose of this. And truthfully, Natalie, the craziest part, and this is in the studies, after you're cured from using a microdose and rewiring it for say 12 weeks, 14 weeks, it doesn't come back.

So it actually changes the stuff patterning and the brainwave patterning pretty much permanently. So a lot of people can then withdraw from the drug and not have those addictive compulsive desires or

Natalie Tysdal (14:04)

So it actually changes the stuff in the brain wave pattern pretty much permanently. So a lot of people end up withdrawing from the drug and not have those addictive desires

Jay Campbell (14:15)

come back.

Natalie Tysdal (14:15)

whatever

come back. When you talk about a microdose, what are you talking about? What's an effective dose for weight loss versus a microdose?

Yeah, so in truth, a microdose is effective for

Jay Campbell (14:23)

Yeah, so in truth, a microdose is effective for weight loss.

The problem that we have is that the pharmaceutical studies, not all of them, but most of them start at very superphysiologic levels. And this is way too high. And the reason, you know, the people that work in studies and they're called randomized placebo-controlled trials or RPCTs is they're starting with very unhealthy people. When you do studies, especially for weight loss drugs or fat loss drugs, it's always in diabetics, obese.

Natalie Tysdal (14:29)

not all of them, but most of them are at very superphysiologic levels. And this is way too high. And the reason, you know, the people that work in studies and they're called randomized placebo controlled trials or RPCPs, starting with very unhealthy people. When you do studies, especially for weight loss drugs or fat loss drugs, it's always in diabetics, obese,

people in resistance. So you're never dealing with a healthy population or otherwise normal people.

Jay Campbell (14:53)

insulin resistant, so you're never dealing with the healthy population or otherwise normal people. So these

Natalie Tysdal (14:58)

So these people are always going to be put on the highest dose. Because at the same time, they're not also, and some of the studies do, but very few. They're not counseled to change their lifestyle. They're not counseled to eat cleaner, to exercise, to live insulin controlled, et cetera. you've got to take the studies with a grain of

Jay Campbell (14:58)

people are always going to be put on the highest dose because at the same time, they're not also, and some of the studies do, but very few, they're not counseled to change their lifestyle. They're not counseled to eat cleaner, to exercise, to live insulin controlled, et cetera. So you got to take the studies with a grain of salt.

Natalie Tysdal (15:16)

salt. Over time, you have to realize that, again, they're giving you super high dosages because they're so inflamed and so insulin resistant.

Jay Campbell (15:16)

And then over time, you have to realize that again, they're giving these people super high dosages because they're so inflamed and so insulin resistant. But

if you give an insulin resistant and inflamed person who's heavy, obese even, a smaller dose, who's never been exposed to a GLP previously, they're going to get the same response as a healthier person because of the way the signaling processes work in the body. The problem is, is that majority of people who do start these, whether they're healthy or heavy,

Natalie Tysdal (15:25)

You give an insulin resistant and inflamed person who's heavy, obese even.

smaller dose who's never been exposed to a GLP previously, they're going to get the same response as a healthier person because of the way the signaling says is working the body. Problem is, is that majority of people who do start these, whether they're healthy or heavy,

Jay Campbell (15:46)

start at too high of a dose. Because again, if you're the pharmaceutical company, you want the pharmaceutical manufacturer and of course the drug rep and then the doctor to start at the highest dose and then stair step higher and higher and higher. Because that's how everybody gets paid,

Natalie Tysdal (15:46)

Jay Campbell (15:59)

right? It's the old pharma regime or the pharma hierarchy of more money, more power, more people getting paid. But if you realize that you don't have to do that, you'll get the same effect, especially

Natalie Tysdal (16:00)

It's the old pharma regime or the pharma hierarchy of more money, more power, more people getting paid. But if you realize that you don't have to do that, you'll get the same effect, especially

over time. Because the one thing the studies show, which is conclusive, you start at a lower dose.

Jay Campbell (16:13)

over time because the one thing the studies show, is conclusive, if you start at a lower dose and you

control the dosing and you barely stare stuff ever, you just kind of keep it mediated. And then of course the person does the right lifestyle thing. Those people keep the weight off versus the people that take the higher dose and just whack out the receptors become addicted to the high level and then have to continually go from different GLP drug to different GLP drug because the receptors are shot.

Natalie Tysdal (16:21)

control the dosing and you barely start stuff ever you just kind of keep it mediated and then of course the person does the right lifestyle thing those people keep the weight off this is the people that take the higher dose this whack out the receptors become addicted to the high level

and then have to continually go from different drug to different GLP drug because the receptors

are shot. they develop like that, it's called receptor attenuation, but they basically develop a addiction to that high level. But now it doesn't work anymore. So now I have to find another GLP. So that's when you really start looking into it. see that some of these people jump from GLP two to GLP three to GLP one and just various different drugs because their bodies.

Jay Campbell (16:43)

So they've developed, it's called receptor attenuation, but they basically developed an addiction to that high level dose and now it doesn't work anymore so now I have to find another GLP. So that's when you really start looking into it, you see that so many of these people jump from GLP2 to GLP3 to GLP1 and just various different drugs because their bodies have

developed a tolerance to what they're taking.

Natalie Tysdal (17:03)

have developed a tolerance to what they're

taking.

talking about that, GLP one, two, three, I don't know the difference. When someone's out there thinking, okay, maybe I do want to give this a try. I've heard it for a few years. I'm struggling. Where do they start? With their general practitioner somewhere else, all these online companies. Like, how does someone know the best place

start?

Jay Campbell (17:27)

Yeah, it's a great question. So let me explain first off the difference. So GLP-1 is like the first generation of GLP drugs. And all it means is it's an agonist for appetite suppression. So GLP-1 is ⁓ appetite suppression. GLP-2, and by the way, so let me name these so people know what them, GLP-1 would be like semaglutide, which is with govee, which most people that listen to you know what that is. And that's a very old school.

Natalie Tysdal (17:36)

it's an agonist appetite suppression. So GLP-1 is appetite suppression. GLP-2, and by the way, so let me name these so people know what that, GLP-1 would be like semaglutide, which is with GILP, which most people that listen to you know what that is. And that's a very old school,

early level appetite suppressing drug, very powerful, it works.

Jay Campbell (17:54)

early level appetite suppressing drug, very powerful. works. The

problem with it is that a lot of people take too high of a dose. does cause nausea. You know, it's like a food aversion. You're like, I don't want to eat, you know, and then there's the same people that don't eat for five days, right? Because they don't want to have a, they don't want to eat. have no appetite. So that's not good, but that's again, a very crude version version two or type or a GOP two is trisapid, which is also known as Manjaro or

Natalie Tysdal (17:59)

problem with it is that a lot of people take too high of a dose. It does cause nausea. It's like a food aversion. You're like, don't want to eat. And then there's the same people that don't eat for five days because they don't want to eat. They have no appetite. So that's not good. But that's again, a very crude version. Version two or type of P2 is trisapatite, which is also known as mangarro for,

Jay Campbell (18:24)

⁓ I forget the other one. ⁓

Natalie Tysdal (18:25)

I forget the other one.

Jay Campbell (18:27)

What is it? Manjaro and Zep, not Zep, Zepbound? Yeah, I think it's Zepbound. Yeah. So those are basically appetite suppressants and then also glucogen, which is kind of a metabolic activator in the body, stimulator. So it's kind of upregulating metabolism a little bit. So that's obviously much better than a GLP-1, which is just appetite suppression because obviously you want to stop eating as much and then you also want your metabolism to increase.

Natalie Tysdal (18:28)

Manjaro and Zet-bound. So those are basically tight suppressants, also glucogen, which is kind a metabolic activator in the body, stimulator. So it's kind of regulating metabolism a little bit. So that's obviously much better than Lp1, which is just appetite suppression, because obviously you want to stop eating as much, and then you also want your metabolism

Jay Campbell (18:53)

And then the next one, which is the newest one and the one that's not FDA approved yet, but it will be this year, is called Rutter True Tide. And that's Eli Lilly drug, and Eli Lilly also owns Terzapatide GLP2. So once they have this drug in the marketplace, they're gonna become a bazillion dollar company. They're already a trillion dollar market cap company. So you can only imagine like how much money this company has. But I use this product, my wife uses this product. If you microdosed Rutter True Tide, ⁓ it...

Natalie Tysdal (18:53)

And then the next one, the newest one, and the one that's not FDA approved yet, but it will be this year, is called Rutter True Tide. And that's Eli Lilly drug, and Eli Lilly also owns Terzapatide GLP2. So once they have this drug in the marketplace, they're gonna become a bazillion dollar company. They're already a trillion dollar market cap company, so you can only imagine the kind of money this company has. But I use this product, my wife uses this product. If you've microdosed Rutter True Tide, it...

Jay Campbell (19:21)

improves

metabolism, improves nutrient partitioning and insulin signaling, and it also, in some people, reduces appetite. But you get all the other enhanced metabolic benefits of a GLP-3 versus a GLP-1. So my argument, and I talked about this in the book, is there's really no purpose for GLP-1 anymore, other than that a lot of the insurance companies, because you asked that question, still have that in the Rolodex.

Natalie Tysdal (19:22)

improves metabolism, improves nutrient partitioning and insulin signaling and it also some people.

Jay Campbell (19:47)

because it's a it's the cheapest and B it's the most understood from a scientific study standpoint. So they're still putting that out there to a lot of people. But as I will continue to say, it's very crude now because we have much better tools in GLP two and GLP three and very truthfully, and this is also in the book, GLP four and GLP five are in the pipeline. So like in the next year to year and a half, we're going to be talking about GLP two and GLP one is irrelevant. No one will even consider them because there'll be better drugs coming. So

Natalie Tysdal (19:58)

We have much better tools in GLP2 and GLP3. And very truthfully, and this is also in the book, GLP4 and GLP5 are in the pipeline. So like in the next year to year and a half, we're going to be talking about GLP2 and GLP1 as a realm. No one will even consider that because there'll be better drugs coming.

So we really are in a pharmacological slash biomedical revolution. It's almost a golden age. But as you said from the very beginning of show, people have to become educated about how to use these because if they just go to their, you

Jay Campbell (20:15)

We really are in a pharmacological slash biomedical revolution. It's almost a golden age. But as you said from the very beginning of the show, people have to become educated about how to use these because if they just go to their general

practitioner or their garden variety doctor, they're not going to get good information. So that's what my book really does a good job of is educating both the population and hopefully the clinical community because it's written for clinicians. There's lots of science.

Natalie Tysdal (20:32)

So that's what my book really does a good job of is educating both the population and hopefully the clinical community because it's written for clinicians. There's lots of science,

right? But it's also written in very lay terms so that an average person can just read it and get to the bottom of like, okay, can you tell me what dose I need to use and tell me what lifestyle changes I need to make so that I can look and feel my absolute best. So the only thing we haven't talked

Jay Campbell (20:41)

But it's also written in very lay terms so that an average person can just read it and get to the bottom of like, okay, do you tell me what dose I need to use and tell me what lifestyle changes I need to make so that I can look and feel my absolute best. So I think the only thing we haven't talked about

in this podcast yet or this interview is doses.

Natalie Tysdal (20:57)

interview is

Jay Campbell (20:59)

if you want to get into that, we can talk about that.

Natalie Tysdal (20:59)

if you want to get into Yeah, I want

to talk about doses, but I also want to touch on because I interview a lot of doctors and there are a lot of good doctors out there. But there are some that keeping up with this.

Jay Campbell (21:05)

Sure. There are. But there's something keeping up with

Natalie Tysdal (21:11)

is like going back to medical school. Like

Jay Campbell (21:11)

it. Exactly.

Natalie Tysdal (21:13)

you can't just do what you've done for 20, 30 years and expect that there aren't changes. asking the right and this is where I try to empower my listeners, asking the right questions, like having this information, doctor might not like it too much if you know more than they do. But by saying like, I have heard this explain this to me, if you're not getting the answers or you're not getting what you think you need to be OK.

Jay Campbell (21:15)

Yep. Yep. Yep.

Exactly.

Natalie Tysdal (21:37)

asking a different doctor or going to a new practice. And I know that's a lot of work, but I think you've

Jay Campbell (21:42)

But that's 100

Natalie Tysdal (21:43)

% accurate. I've been actually saying that for 12, 13 years since I started lecturing and started talking at medical conferences to have the right and the authority to get a better doctor. Like if your doctor doesn't know, find another doctor. You're not obligated to listen to that doctor. And very truthfully, you said that there are great clinicians out there that do understand how to use GOP.

Jay Campbell (21:43)

accurate. I've been actually saying that for 12, 13 years since I started lecturing and started talking at medical conferences. You have the right and the authority to get a better doctor. Like if your doctor doesn't know, find another doctor. You're not obligated to listen to that doctor. And very truthfully, you said it best. There are great clinicians out there that do understand how to use GLPs.

Listen, there's not a single doctor who understands this at the level that someone like I understand it.

Natalie Tysdal (22:04)

Listen, there's not a single doctor understands this at the level that someone like I understand

it, who isn't recommending secretose products. They understand how it works. understand the receptor sensitivity, understand receptor desensitization, understand how these work and also how to make them work. These folks, like if you're working with them, they're going to help you, but you surely cannot go to a garden variety general practitioner or HMO doctor.

Jay Campbell (22:10)

who isn't recommending microdose of the products, because they understand how it works. They understand the receptor sensitivity. They understand receptor desensitization. They understand how these work and also how to make them not work, right? So these folks, like if you're working with them, they're going to help you, but you surely cannot go to a garden variety general practitioner or HMO doctor and expect

them to understand the nuance of prescribing these, because you already said it, they don't.

Natalie Tysdal (22:34)

expect them to understand the nuance of driving these because you already said they

don't and they don't have the time to learn either because it's not part of their deal. just make sure you're working with a position that has, would say, an experiential body of work. Like you should actually make sure that your doctor's been prescribing GLPs for a minimum of four if not five years because they have been in the

Jay Campbell (22:38)

and they don't have the time to learn either because it's not part of their deal. So just make sure you're working with a physician that has, I would say an experiential body of work. Like you should actually make sure that your doctor's been prescribing GLPs for a minimum of four, if not five years. Cause they have been in

Natalie Tysdal (22:53)

since 2010. What about the online companies where you can fill out a survey and then have it sent to you?

Jay Campbell (22:53)

public since 2020.

Natalie Tysdal (23:01)

going to use those. not against

Jay Campbell (23:01)

If you're going to use those, not against them. I

work with a lot of those people. In fact, the guy that runs scripts was just texting me while we're on this podcast right now. He wants to talk to me about some of our products, but those are great companies in that they can give you a discount that your doctor is not going to be. It's kind of like good Rx for prescription drugs, right? Like if you have the app on your phone, you might get 30 % off than what your doctor writes you a script to go to Rite Aid or Walgreens or Walmart or whatever for your pharmacy.

Natalie Tysdal (23:04)

work with a lot of those people. fact, the guy that runs scripts, next to me, why we're on this podcast right now. wants to talk to you about some of our products, those are great companies in that they can give you a cow. The doctor is not going to be, it's kind of like good RX for drugs. You have the app on your phone, you might get 40 % off.

Jay Campbell (23:30)

So just make sure if you use them that you really do have a good understanding of how to use these again, within the context of microdosing and health and longevity. And again, my book will give you the perfect ⁓ playbook if you want to call it on like how to do that. ⁓ I think they're great. I really do think they're great because you can get a serious discount on a volume. But just don't go into it.

Natalie Tysdal (23:30)

So just make sure if you use them that you really do have a good understanding of how to use these, again, within the context of microdosing and health and longevity. And again, my book will give you the perfect ⁓ playbook if you wanna call it on like how to do that. ⁓ I think they're great. I really do think they're great because you can get a serious discount on volume.

but just don't go into

it and buy it from them because they're not really able to educate you. Some of them can, some of them have good education arms, but I wouldn't rely on them from an education standpoint. If you're one of those people and you're buying from one of those companies like a Scripps or a Loo-O,

Jay Campbell (23:54)

and buy it from them because they're not really able to educate you. Some of them can, some of them have good education arms, but I wouldn't rely on them from an education standpoint. If you're one of those people and you're buying from one of those companies like a Scripps or a Luo or one

of those big companies, make sure you're armed educationally to understand how to use those if you

Natalie Tysdal (24:09)

Make sure your arm educationally to understand how to use

Jay Campbell (24:13)

with them. ⁓

Natalie Tysdal (24:13)

if you start to look down. Yeah. Okay. Let's talk about the dosage. A lot

of people stare, climb up, and then they lose the weight. And then as you mentioned, they have a hard time. What is a micro dose? ⁓ Like give me the numbers and how you manage that.

So it's a great question. So it depends on which GOP you're using. Like for example, a a pharmacological.

Jay Campbell (24:27)

so it's a great question. So it really depends on which GLP you're using. Like for example, a standard dose, a pharmacological recommended

dose for a say GLP-1, which is against semaglutide or with govi, is somewhere between three and five milligrams. Now, if you have never used a GLP-1 or any GLP and you start with five milligrams, you're not going to do well.

Natalie Tysdal (24:36)

dose for a say GLP-1 which is against Senaglutide or Legobi is somewhere between 3 and 5 milligrams. Now if you have never used a GLP-1 or any GLP and you start with 5 milligrams you're not going to

do well. You're going to be completely overwhelmed, you're going to have zero appetite for two or three days, going to really you're going to have like no bowel movements, you're going to have some issues.

Jay Campbell (24:50)

You're going to be completely overwhelmed. You're to have zero appetite for two or three days. You're going to really, you're going to have like no bowel movements. You're going to have some issues.

And so if you were doing that correctly, and again, very few people do this, but if you were understanding how to use GLP-1 correctly, you would literally start with like, depending on your size, ⁓ somewhere between 0.25 and 0.5 milligrams. So you're literally now talking like one 10th dose that the pharmacological or the pharmaceutical company wants you to start at.

Natalie Tysdal (25:00)

So we're doing that correctly. again, there are some people do this, but if you were understanding how to use GLP one correctly, you would literally start with like, depending on your size.

between 0.25 and 0.5 milligrams. So you're literally now talking like one-tenth of those that the pharmacological or the pharmaceutical company wants you to start

at. And that would be moved to like DLP2 or GLP3. I did the same thing. DLP2 is like 2.5 to 4 milligrams starting, whereas I recommend 0.25 to 0.35 milligrams starting. And the same thing with Routetrootide with the GLP3. They give people like six or eight milligrams

Jay Campbell (25:20)

And now if we move to like GLP 2 or GLP 3, it's kind of the same thing. GLP 2 is like 2.5 to 4 milligrams starting, whereas I recommend 0.25 to 0.35 milligrams starting. And the same thing with TruTide, which is GLP 3. They give people like six or eight milligrams

Natalie Tysdal (25:40)

tiny two times a week instead okay

Jay Campbell (25:40)

of not a week to start the first dose. And that's insane. I never use more than 0.

six or 0.75 milligrams total a week. And I will inject myself usually three times a week, sometimes only twice, depending on how much I'm traveling. My wife injects twice a week and she takes 0.15

So again, it's a

micro dose to improve

metabolic rate, improve nutrient partitioning, improve insulin signaling.

So all the good things that these drugs do, again, in the research to improve your body's ability to burn through calories, have more energy, have better brain power, and then ultimately just live leaner longer, right? Because that's what it's doing. And the other thing, and I didn't talk to you about, this is important, I think, especially for the science and the clinical people. I've been using these since 2020 and all my biomarkers have improved. Like I have never been healthier from an actual blood measurement.

Natalie Tysdal (26:15)

to improve your body's ability to burn through calories, have more energy, have better brain power, and then ultimately just live leaner longer, right? Because that's what it's doing. And the other thing that I need to talk to you about, which is important, think, especially for the science and the clinical people, I've been using these since 2020, and all my biomarkers have improved.

Like I have never been healthier from an actual blood measurement

Jay Campbell (26:40)

standpoint than I am now. I know, and again, the research shows this, that that's how powerful these drugs are, that when you use them correctly, and again, microdose fashion, you're improving all of your longevity markers. So there's no question that people will improve from all levels if they, again, change their lifestyle, which is always first and foremost, and then use these drugs in microdose fashion. And then to your question to add,

Natalie Tysdal (26:41)

than I am now. So I know, and again, the research shows that that's how powerful these drugs are. But when you use them correctly, and again, microdose fashion, you're improving all of your longevity markers. So there's no question that people will improve all levels if they, change their lifestyle, if they always first and foremost, and then use these drugs in microdose fashion. And then to your question, to add.

You can easily, again, depending on what you're using for it, you're using it for food noise or

Jay Campbell (27:05)

you can easily, again, depending on what you're using them for, if you're using it for food noise or to

Natalie Tysdal (27:09)

to get rid of a bad, a pesky, compulsive thing versus actually losing them for fat loss, know, actually improving metabolic rate. You could probably go on for two or three months and then stair step completely down. And by the way, you asked about stair stepping, you don't have to go up at all. If you stay there.

Jay Campbell (27:09)

get rid of a bad obsessive compulsive thing versus actually losing them for fat loss, actually improving metabolic rate, you could probably go on for two or three months and then stair step completely down. And by the way, you asked about stair stepping. You don't have to go up at all. If you stay at that, say, 0.5, 0.75,

Natalie Tysdal (27:29)

point seven point six a week and maybe maybe if you're really happy and really influenced this regulated maybe a tiny bit

Jay Campbell (27:30)

0.6 a week, and maybe if you're really happy and really insulin-disregulated, maybe you can go up a tiny bit.

But you don't have to continue to stair step your dose because your body will get used to the amount it's giving it. And it will change your body's signaling cascades and metabolic cascades to improve all the pathways that you're looking to work that the GLP addresses anyway. there's never a reason to go higher in dosage. The people that do that are getting the bad advice again from

Natalie Tysdal (27:37)

but you don't have to continue to research that because your body will get used to the amount that's giving it it will change your body's signaling cascades and metabolic cascades to improve all the pathways that you're looking to work that the GLP addresses anyway so there's never a reason to go higher in dosage the people that do that are getting that advice

Again, from the wraps and from pharma companies because they want them to get more money

Jay Campbell (27:59)

the pharmaceutical reps and from the pharma companies because they want them to get more money.

to increase the dose and to get the person more addicted to the product. But if you really understand the pharmacology or the pharmacokinetics or the PK curve of these drugs, there's no need to increase the dosage because they work so well already.

Natalie Tysdal (28:04)

Yeah, it's so fascinating and I've watched so many people

get healthy and then I've watched some who, like I said, they've lost too much weight. I think the addictive nature, not that the drug is addictive, they get addicted to losing, losing, losing and it's like they don't know where to stop.

Jay Campbell (28:33)

When you see people's

called out and collapsed, you can definitely tell

a person who's abused at GLP. And as you said, most likely is addicted to the feeling of the GLP, which is like, I don't have to eat. You know what mean? And they're just constantly playing this yo yo lifestyle of like, you know what? I'm starving, but I don't want to eat. So I'll increase my dose. It's really, really weird. But if you start right. And again, that's what the micro dose.

Natalie Tysdal (28:40)

Yeah. ⁓

It's really, really weird. if you start right, and again, that's with a micro dose,

and you make sure you adhere to the lifestyle things that we talked about earlier in the show, I've never seen anybody fail to see people just look at them as a tool. Yeah. And it's like, can come off of this for two months if I want to and maintain my weight, or maybe I want to indulge.

Jay Campbell (28:58)

And you make sure you adhere to the lifestyle things that we talked about earlier in the show. I've never seen anybody fail. And I see people just look at them as a tool, you know, and it's like, Hey, I can come off of this for two months if I want to and maintain my weight, or maybe I want to indulge, but

I always know I have that tool that I can go back to at a micro dose if I need to lose five pounds or I need to lose seven pounds, or I need to just kill the food noise that came back after I came off of it for 90 days. So again, they're just tools. They're not something to rely on.

Natalie Tysdal (29:14)

I always know I have that tool that I can go back to at a micro dose if I need to lose five pounds or I need to lose seven pounds or I need to just kill the food noise that came back after I came off of it for 90 days. again, they're this tool. They're not something to rely

on. You should not be thinking about getting addicted to them or completely suppressing your appetite. They're just something to use in the context of all the other good things when you have your

Jay Campbell (29:27)

You should not be thinking about getting addicted to them or completely suppressing your appetite. There's just something to use in the context of all the other good things when you have your lifestyle

Natalie Tysdal (29:36)

Yeah. Well, what we didn't get to talk about, and I want to schedule a time because I know your history in hormones, women's hormones,

I know you've done a lot with Benz and your own. So let's find another time because I think that as you mentioned like it's really important to get that right before we do this.

Jay Campbell (29:48)

I'd love to.

It is. Yeah, and honestly, I'll just

it with this. I would just say that if you're

a woman and you're watching this show and you heard a lot of good stuff from me today on how to use it, you want to start these. First thing for sure is to get your hormones checked because if you're in your 40s, 50s or 60s and you're functioning with a hormone deficiency or dysregulation, and again, many are, you don't want to start these drugs, even in a microdose, because they are so powerful.

Natalie Tysdal (30:00)

I don't know how you use it. want to start these. First thing for sure is to get your hormones checked because you know if you're in your 40s, 50s or 60s and you're functioning with a hormone deficiency or dysregulation and again many are, you don't want to start these drugs even in a micro dose because they are so powerful.

Jay Campbell (30:17)

You know, remember the last thing you can do to afford as you're getting older is lose muscle, right? I mean, if you want to live leaner, longer, the number one way to do that is to be muscular,

Natalie Tysdal (30:17)

You know remember the last thing you can do to afford as you get older is lose muscle right? I if you want to live leaner longer but one way to do that is to be

Jay Campbell (30:25)

right? Not bodybuilding jacked, but just, you know, lean and sexy and toned. And that's how you live the longest. And again, in the blue zones and the octogenarians, we know that the people that live the longest have the lowest inflammation. So the more muscle that you have on your body, you know, again, not bulky muscle, but tone muscle, the longer you're going to live. It's just facts.

Natalie Tysdal (30:26)

right? Not bodybuilding jack. Yeah, but just, lean and sexy and tone. And that's how you live the longest. And again, in the blue zones and the oxygen area, we know that the people that live the longest have the lowest inflammation. Yes. So the more muscle that you have on your body, you know, they're not bulky muscle, the tone muscle, the longer you're to live. It's just a

fact.

it's just it's just healthy. All right, well, let's find another time. We'll talk we'll talk hormones only and regulating those and how to do so. Jay, thank you so much. Best of luck with the new book. I look forward to digging into it. And I will be sure and put all the links so people can find you the book and so on in the show notes.

Jay Campbell (30:48)

Exactly.

Thank you, Natalie. I really appreciate it.

Thank you so much.